carboplatin + dexamethasone + gemcitabine

This is a combination chemotherapy regimen consisting of three drugs: - **Carboplatin** is a platinum-based chemotherapeutic agent that forms DNA crosslinks, leading to apoptosis in rapidly dividing cells. - **Gemcitabine** is a nucleoside analog (antimetabolite) that inhibits DNA synthesis by incorporation into DNA and inhibition of ribonucleotide reductase. - **Dexamethasone** is a synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressive properties; in oncology regimens it also helps reduce chemotherapy-induced nausea and manage certain side effects. The combination has been used as salvage therapy for relapsed or refractory lymphoma, including non-Hodgkin lymphoma and Hodgkin lymphoma. It may be administered as an alternative to similar regimens where cisplatin is replaced by carboplatin due to renal dysfunction or toxicity concerns. The regimen can be given on an outpatient basis and has demonstrated efficacy with manageable toxicity profiles, primarily myelosuppression[1][2][3][5].

Other names

GCDGDCGDP (when cisplatin is substituted with carboplatin)gemcitabine/carboplatin/dexamethasone