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carboplatin + docetaxel + thiotepa
- Development stage
- Unknown
- Lead developer
- Johnson Matthey
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This is a combination chemotherapy regimen consisting of three agents—carboplatin, docetaxel, and thiotepa. Carboplatin is a platinum-based antineoplastic agent that forms DNA crosslinks, inhibiting DNA replication and transcription. Docetaxel is a taxane that stabilizes microtubules, preventing cell division. Thiotepa is an alkylating agent that introduces alkyl groups into DNA bases, leading to DNA damage and cell death. The combination has been explored in high-dose chemotherapy settings for solid tumors (including pediatric solid tumors) and as part of regimens before autologous stem cell transplantation[2][3][5]. The regimen aims to maximize tumor cell kill by combining drugs with different mechanisms of action.
- Other names
- carboplatin/docetaxel/thiotepathiotepa/carboplatin/docetaxel
02
Targets
DNATUBB (Tubulin (alpha and beta subunits))
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