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carboplatin + Endostar + vinorelbine
- Development stage
- Unknown
- Lead developer
- Simcere Pharmaceutical Group
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous, Oral
01
Overview
A combination chemotherapy regimen consisting of carboplatin (a platinum-based chemotherapy), Endostar (recombinant human endostatin), and vinorelbine (a vinca alkaloid). This combination targets cancer through multiple mechanisms: carboplatin interferes with DNA replication, Endostar inhibits angiogenesis, and vinorelbine blocks cell division by disrupting microtubules. It is primarily used in the treatment of non-small cell lung cancer (NSCLC), particularly lung squamous cell carcinoma (LSCC).
02
Targets
DNAHSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))ITGA5:ITGB1 (Integrin α5β1)NCL (Nucleolin)TUBB (Tubulin (alpha and beta subunits))VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)Microtubule
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