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carboplatin + endostatin + paclitaxel
- Development stage
- Unknown
- Lead developer
- Johnson Matthey
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of carboplatin (a platinum-based chemotherapy), endostatin (an anti-angiogenic agent), and paclitaxel (a taxane chemotherapy). This regimen works through multiple mechanisms: carboplatin forms DNA crosslinks preventing cancer cells from dividing properly; paclitaxel stabilizes microtubules, preventing their breakdown during cell division and thus inhibiting cancer cell proliferation; and endostatin inhibits angiogenesis by blocking pro-angiogenic growth factors such as basic fibroblast growth factor and vascular endothelial growth factor.
- Brand names
- ParaplatinEndostarTaxol
- Other names
- Carbo/Taxol + EndostarPC + Endostar
02
Targets
TUBB (Tubulin (alpha and beta subunits))FGF2C5AR1 (Complement C5a receptor 1)DNAVEGF/VEGFR (Vascular endothelial growth factor and vascular endothelial growth factor receptor)
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