Drug intelligence / Profile preview

carboplatin + gefitinib + paclitaxel

Development stage
Phase 3
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

A combination therapy consisting of carboplatin (a platinum-based chemotherapy agent), gefitinib (an epidermal growth factor receptor tyrosine kinase inhibitor), and paclitaxel (a taxane chemotherapy agent). This regimen has been studied in clinical trials for advanced non-small cell lung cancer (NSCLC), particularly in chemotherapy-naive patients. The combination can be administered with gefitinib given concurrently or in an intercalated fashion with the chemotherapy.

Brand names
Iressa (for gefitinib)Taxol (for paclitaxel)Paraplatin (for carboplatin)
Other names
PTXCBDCAZD1839ZD-1839ZD 1839
02

Targets

DNAEGFR (Epidermal growth factor receptor)TUBB (Tubulin (alpha and beta subunits))

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