carboplatin + gemcitabine + Iscador

This is a combination regimen consisting of two chemotherapeutic agents—carboplatin and gemcitabine—together with Iscador, a standardized extract of mistletoe (Viscum album). Carboplatin is a platinum-based compound that induces DNA crosslinking and apoptosis in rapidly dividing cells. Gemcitabine is an antimetabolite nucleoside analog that inhibits DNA synthesis by incorporating into DNA strands during replication. Iscador (mistletoe extract) is used as a complementary therapy in oncology; it contains various bioactive compounds believed to modulate the immune system and potentially reduce chemotherapy-related toxicity. This combination has been studied primarily in advanced non-small-cell lung cancer (NSCLC), where the addition of Iscador to standard carboplatin/gemcitabine regimens did not significantly affect overall survival or quality of life but was associated with fewer severe non-hematological toxicities and hospitalizations[1][7][8]. Preclinical studies suggest no negative pharmacokinetic interactions between mistletoe extracts and chemotherapeutic agents such as gemcitabine[7][8].

Other names

carboplatingemcitabineIscadormistletoe extract