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carboplatin + gemcitabine + selumetinib

Development stage: Unknown
Lead developer: AstraZeneca
Modality: Small Molecules
Administration: Intravenous, Oral

Overview

A combination therapy consisting of carboplatin (a platinum-based chemotherapy agent), gemcitabine (a nucleoside analog), and selumetinib (an oral MEK1/2 inhibitor). This combination has been investigated in clinical trials for advanced non-small cell lung cancer (NSCLC). Selumetinib blocks signals that cancer cells use to divide and grow by inhibiting MEK1/2, while carboplatin and gemcitabine work as cytotoxic agents to kill cancer cells.

Targets

RNR (Ribonucleotide reductase)MEK2 (Dual specificity mitogen-activated protein kinase kinase 2)DNA polymerase familyDNAMEK1 (Dual specificity mitogen-activated protein kinase kinase 1)

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