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Drug intelligence / Profile preview
carboplatin + lenvatinib + pembrolizumab + pemetrexed
- Development stage
- Phase 3
- Lead developer
- Johnson Matthey
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination therapy consisting of carboplatin (a platinum-based chemotherapy agent), lenvatinib (a kinase inhibitor), pembrolizumab (an immune checkpoint inhibitor), and pemetrexed (a folate analog metabolic inhibitor). While individual components and some combinations of these drugs are used in cancer treatment, this specific four-drug combination is not clearly documented in the provided search results.
02
Targets
DNADHFR (Dihydrofolate reductase)FGFR (FGFR family)GART (GAR transformylase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDCD1 (Programmed cell death protein 1 receptor)PDGFRA (Platelet-derived growth factor receptor alpha)RET (Rearranged during transfection receptor tyrosine kinase)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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