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carboplatin + SonoCloud-9
- Development stage
- Unknown
- Lead developer
- CarThera
- Modality
- Small Molecules
- Administration
- Intravenous, Intracranial
01
Overview
Carboplatin + SonoCloud-9 is a combination therapy developed by the French medtech company CarThera for the treatment of glioblastoma. The approach pairs the systemic administration of carboplatin, a platinum-based chemotherapy agent, with the SonoCloud-9, an implantable medical device. The SonoCloud-9 is surgically placed into the skull and utilizes low-intensity pulsed ultrasound to transiently disrupt the blood-brain barrier (BBB) upon activation. This temporary opening allows therapeutic concentrations of carboplatin—which is typically restricted by the BBB—to reach the brain tumor tissue and the surrounding infiltrative zone. The combination is currently under evaluation in the pivotal Phase 3 SONOBIRD trial for patients with first-recurrence glioblastoma.
- Brand names
- SonoCloud-9SonoCloud9SonoCloud 9
- Other names
- Carboplatin with SonoCloud-9Carboplatin-CarTheraSonoCloud-9 with carboplatinSonoCloud9 with carboplatinSonoCloud 9 with carboplatin
02
Targets
DNA
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