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Drug intelligence / Profile preview
carboxylated zinc phthalocyanine
- Development stage
- Preclinical
- Lead developer
- Shimane University
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
Carboxylated zinc phthalocyanine is a water-soluble, macrocyclic metallophthalocyanine compound with near-infrared optical properties being investigated as a therapeutic agent for Alzheimer's disease. Developed by researchers at Shimane University, the compound acts as an amyloid-beta (Aβ) aggregation inhibitor. It physically binds to Aβ peptides, decreasing their hydrophobicity and destabilizing pre-formed fibrils, which prevents the formation of neurotoxic oligomers and fibrils. In preclinical mouse models of Alzheimer's disease, treatment with carboxylated zinc phthalocyanine significantly reduced brain amyloid-beta deposition, decreased glial activation (astrocytes and microglia), increased vessel density, and improved cognitive performance without showing liver or kidney toxicity.
- Other names
- carboxylated Zn-phthalocyanineocta-carboxyl substituted zinc phthalocyaninezinc octacarboxyphthalocyanineZnPc(COOH)8ZnPc(COONa)8ZnPcOC
02
Targets
Aβ (Amyloid-beta peptides and aggregates)
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