Carboxylic PRPP

Carboxylic PRPP, also known as CPRPP, is a synthetic carbocyclic analog of the crucial metabolic intermediate Phosphoribosyl Diphosphate (PRPP). Chemically, it is identified as [(1S,2R,3R,4R)-2,3-dihydroxy-4-(phosphonooxymethyl)cyclopentyl] phosphono hydrogen phosphate, with a molecular formula of C6H15O13P3. Unlike the natural PRPP, which features a ribose sugar ring, Carboxylic PRPP incorporates a cyclopentane ring, making it a stable, optically active carbocyclic analog. PRPP plays a central role in cellular metabolism, serving as a substrate for the biosynthesis of purine and pyrimidine nucleotides, certain amino acids (histidine and tryptophan), and cofactors like NAD and NADP. While Carboxylic PRPP is classified as a pharmaceutical chemical in databases like PubChem, its specific therapeutic indications or development status as a drug are not established; it is primarily recognized as a chemical entity for research, potentially interacting with enzymes involved in PRPP-dependent metabolic pathways.

Other names

[(1S,2R,3R,4R)-2,3-dihydroxy-4-(phosphonooxymethyl)cyclopentyl] phosphono hydrogen phosphatecarbocyclic analog of 5-phosphoribosyl-1-pyrophosphate