Drug intelligence / Profile preview

carboxymethylcellulose + naphazoline

Development stage
Unknown
Lead developer
Ordain Health Care
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Decomic Plus is an ophthalmic combination eye drop formulation containing the vasoconstrictor naphazoline hydrochloride (0.1% w/v) and the lubricant carboxymethylcellulose sodium (0.5% w/v). It is indicated for the temporary relief of eye redness, irritation, discomfort, and dryness caused by minor environmental irritants such as wind, sun, dust, smoke, pool chlorine, or eye strain. Naphazoline acts as a sympathomimetic alpha-adrenergic agonist that constricts dilated conjunctival blood vessels to rapidly clear redness, while carboxymethylcellulose sodium acts as an artificial tear substitute to lubricate and moisturize the ocular surface. Originally developed by Vivimed Labs (Klar Sehen), the product line and trademarks were acquired by Ordain Health Care (a subsidiary of Exeltis) in 2016.

Brand names
Decomic Plus
Other names
carboxymethylcellulose sodium + naphazoline hydrochloridenaphazoline + carboxymethylcellulose
02

Targets

ADRA2A (α2A)ADRA1A (α1A)ADRA1 (Alpha-1 adrenergic receptor family)

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