carbromal

Carbromal is a sedative and hypnotic small molecule drug originally synthesized in 1909 by Bayer. It was marketed under several brand names, including Adalin, and used primarily for the treatment of mild insomnia and as a calming agent[1][3][4]. Carbromal acts as a central nervous system depressant by enhancing GABAergic neurotransmission through positive allosteric modulation of the GABA-A receptor, increasing chloride influx into neurons and resulting in neuronal inhibition[6]. The drug releases bromide ions upon hydrolysis in the body; chronic use can lead to accumulation of bromide ions (bromism), which may cause neurological and dermatological symptoms[4]. Carbromal has largely been replaced by safer hypnotics but has seen continued or historical use in some countries, sometimes in combination products such as Carbrital (with pentobarbital) or Demalgon (with aminophenazone)[1].

Brand names

AdalinCarbritalDemalgonAdisomnolDormiturinPianadalinPlanadalinFydalinKarbromalKartrylNenesinParkosedPelidormNyctalTildinUradalMirfudormPersomninServadormThalambrolSomben

Other names

(2-Bromo–2–ethylbutyryl)ureaBromadalBromacetocarbamideBromodiethylacetylureaAddisomnol2-bromo-N-carbamoyl–2–ethylbutanamideBromdiethylacetylureaBromodiethylacetylcarbamideBromacetocarbamidumButanamide, N-(aminocarbonyl)-2-bromo–2–ethyl–1-Bromo–ethyl-butyryl–urea