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Cardi-Braun
- Development stage
- Unknown
- Lead developer
- B. Braun
- Modality
- Small Molecules
- Administration
- Intracardiac
01
Overview
Cardi-Braun is a crystalloid cardioplegic solution developed for myocardial protection during major cardiac surgery involving extracorporeal circulation. Developed by B. Braun in collaboration with Hospital Clinico San Carlos, it is designed to induce rapid and reversible diastolic cardiac arrest (asystole). The solution's mechanism of action relies on a high concentration of potassium ions, which depolarizes the myocardial cell membrane and prevents the generation of action potentials. In addition to electrolytes, Cardi-Braun contains buffering agents like histidine and osmotic agents like mannitol to mitigate intracellular acidosis and cellular edema, thereby protecting the heart from ischemia-reperfusion injury during the surgical procedure.
- Brand names
- Cardi-Braun
- Other names
- Cardi-Braun solutionCardioplegia Braun
02
Targets
Kir (Inward-rectifier potassium channels)
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