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Cardiac Targeted AOC
- Development stage
- Preclinical
- Lead developer
- Aera Therapeutics
- Modality
- Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antibody Conjugates → Antibody-Based Therapeutics
01
Overview
Cardiac Targeted AOC is an investigational antibody-oligonucleotide conjugate (AOC) being developed by Aera Therapeutics. The therapeutic is designed to utilize the high specificity of a monoclonal antibody to deliver an oligonucleotide payload directly to cardiac tissue. By targeting specific cell-surface markers within the heart, the conjugate aims to overcome the historical challenges of delivering RNA-based medicines to cardiomyocytes. This targeted approach is intended to maximize therapeutic efficacy while minimizing systemic off-target effects. As of early 2024, the program is in the lead optimization phase, though the specific molecular targets and primary cardiovascular indications have not yet been publicly disclosed.
- Other names
- Aera Therapeutics cardiac AOCCardiac Targeted Antibody-Oligonucleotide Conjugate
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