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cardiosphere-derived stem cells
- Development stage
- Phase 1
- Lead developer
- Capricor Therapeutics
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intracoronary, Intramuscular, Intravenous
01
Overview
Cardiosphere-derived stem cells (CDCs) are a specific population of cardiac progenitor cells expanded ex vivo from myocardial biopsies. They are characterized by their ability to form multi-cellular clusters called cardiospheres and express markers such as CD105 and c-kit. CDCs function primarily through paracrine signaling, specifically the release of exosomes containing microRNAs and proteins that modulate the immune system, reduce fibrosis, and promote tissue regeneration. Originally developed by researchers at Cedars-Sinai Medical Center and Johns Hopkins University, and currently advanced by Capricor Therapeutics (as CAP-1002), these cells have been investigated for a range of conditions including myocardial infarction, heart failure, and pulmonary arterial hypertension. Currently, the most prominent clinical focus is Duchenne muscular dystrophy (DMD), where the cells' immunomodulatory and anti-fibrotic effects aim to preserve cardiac and skeletal muscle function.
- Other names
- CDCsCardiosphere-derived cellsAllogeneic cardiosphere-derived stem cellsAutologous cardiosphere-derived stem cells
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