carfecillin

Carfecillin is a semisynthetic, orally administered penicillin antibiotic of the carboxypenicillin class. It is the phenyl ester prodrug of carbenicillin, designed to improve oral bioavailability compared to its parent compound. After oral administration, it is hydrolyzed in the body to release active carbenicillin. Carbenicillin acts by binding to and inactivating penicillin-binding proteins (PBPs) on bacterial cell membranes, thereby inhibiting cross-linking of peptidoglycan chains essential for bacterial cell wall synthesis. This disruption leads to weakening and lysis of susceptible bacteria. Carfecillin was primarily used for urinary tract infections and shares many properties with other broad-spectrum penicillins[1][3][4][5][7].

Brand names

Uticillin

Other names

carbenicillin phenylcarfecilinacarfecilline