Drug intelligence / Profile preview

carica papaya leaf extract

Development stage
Phase 3
Lead developer
Bangabandhu Sheikh Mujib Medical University
Administration
Oral, Topical
01

Overview

Carica papaya leaf extract is a **plant-derived botanical extract** prepared from the leaves of *Carica papaya* and has been studied as an oral supportive therapy for **dengue fever**, particularly to mitigate thrombocytopenia and possibly reduce progression to severe disease. In the provided public clinical-trial context, it is administered orally at 1000 mg three times daily for 5 days in placebo-controlled randomized studies of hospitalized or non-severe dengue patients. Its mechanism is **not definitively established** as a single-target pharmaceutical mechanism; reported and hypothesized effects in the literature include **platelet count support, immunomodulatory, antioxidant, and possible membrane-stabilizing or hematopoietic effects**, but it should be treated as a **multicomponent botanical extract rather than a precisely target-defined small-molecule drug**.

Brand names
St. George's Carica Papaya Folia Mother Tincture Q
Other names
papaya leaf extractCarica papaya extract
02

Targets

BCL-2 (BCL-2 family)PIK3CA (Phosphoinositide 3-kinase alpha)

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