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cariprazine
- Development stage
- Approved
- Lead developer
- Gedeon Richter
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Cariprazine is an atypical antipsychotic and a piperazine derivative used primarily for the treatment of schizophrenia and bipolar I disorder, including manic, mixed, and depressive episodes. It is also approved as adjunctive therapy for major depressive disorder (MDD) in adults. Cariprazine acts mainly as a partial agonist at central dopamine D2 and D3 receptors (with higher affinity for D3), as well as serotonin 5-HT1A receptors, and functions as an antagonist at serotonin 5-HT2A receptors. The drug was first developed in Hungary by Gedeon Richter[1][5]. Its mechanism of action involves modulating neurotransmitter activity in the brain to reduce psychosis, mania, depression, and related symptoms[1][3][4].
- Brand names
- Vraylar
- Other names
- cariprazine hydrochloride
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2C (5-hydroxytryptamine 2C receptor)HRH1 (Histamine H1 Receptor)HTR2B (5-Hydroxytryptamine Receptor 2B)DRD3 (Dopamine receptor D3)DRD2 (Dopamine D2 Receptor)
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