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Cariprazine Depot
- Development stage
- Unknown
- Lead developer
- Mapi Pharma
- Modality
- Small Molecules
- Administration
- Subcutaneous
01
Overview
Cariprazine Depot is a long-acting subcutaneous injectable formulation of the atypical antipsychotic cariprazine, developed by Mapi Pharma using its proprietary Depot technology. The drug is designed for once-monthly administration to treat schizophrenia, bipolar I disorder, and major depressive disorder. As a small molecule, it functions as a potent dopamine D3 and D2 receptor partial agonist, notably exhibiting a higher affinity for D3 receptors compared to D2. It also acts as a partial agonist at serotonin 5-HT1A receptors. This long-acting formulation aims to improve therapeutic adherence and reduce the risk of relapse in patients with chronic psychiatric conditions compared to daily oral cariprazine therapy.
- Other names
- Cariprazine LAICariprazine long-acting injectionLong-acting cariprazine
02
Targets
DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)
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