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CARIS-401

Development stage: Preclinical
Lead developer: Caris Life Sciences
Modality: Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

CARIS-401 is a preclinical-stage antibody-drug conjugate (ADC) being developed by Caris Healthcare (Caris Life Sciences) for the treatment of solid tumors. The therapeutic candidate was identified using Caris's proprietary ADAPT (Aptamer-based Drug Discovery and Precision Therapeutics) platform, which utilizes a library of trillions of synthetic oligonucleotides to identify novel cell-surface targets and ligands. As an ADC, CARIS-401 is designed to selectively deliver a cytotoxic payload to tumor cells, thereby maximizing anti-tumor efficacy while minimizing off-target toxicity to healthy tissues.

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