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Caroverine is a small molecule antispasmodic and neuroprotective drug primarily used in Austria and Switzerland for the treatment of smooth muscle spasms, tinnitus (ringing in the ears), and certain cerebrovascular diseases. Chemically classified as a quinoxaline derivative, caroverine acts as a nonspecific calcium channel blocker and an antagonist of NMDA receptors. It also exhibits antioxidant properties by scavenging hydroxyl radicals and reducing oxidative stress. Its mechanism includes relaxing smooth muscles to relieve spasms and blocking glutamate-mediated excitotoxicity in the auditory pathway to alleviate tinnitus symptoms. Caroverine was discovered in Austria in the 1950s and developed by Phafag AG[1][2][5][6][7].
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