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carthamus tinctorius seed oil + kaempferia parviflora rhizome extract
- Development stage
- Unknown
- Lead developer
- Tokiwa Phytochemical Company
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
This botanical combination pairs safflower oil (*Carthamus tinctorius*), a rich source of linoleic acid, with black ginger extract (*Kaempferia parviflora*), which is standardized for polymethoxyflavones such as 5,7-dimethoxyflavone. The primary mechanism of action involves the activation of **Sirtuin 1 (SIRT1)** and **AMP-activated protein kinase (AMPK)**, which are critical regulators of cellular energy metabolism, mitochondrial biogenesis, and glucose homeostasis. Additionally, the black ginger component exhibits inhibitory activity against **phosphodiesterase 5 (PDE5)**. This combination is primarily developed and marketed as a dietary supplement or functional food ingredient intended to support metabolic health, reduce visceral fat, and enhance physical endurance and energy expenditure.
- Brand names
- SirtMax
- Other names
- safflower oil + black ginger extractsafflower oil + krachai dum extractsafflower oil + Thai ginseng extract
02
Targets
PDE5 (Phosphodiesterase 5A)AMPK (Adenosine monophosphate–activated protein kinase)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)
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