casein glycomacropeptide protein substitute

Casein glycomacropeptide protein substitute is a medical food formulated as a protein replacement for individuals with phenylketonuria (PKU), an inherited metabolic disorder requiring strict dietary phenylalanine restriction[1][4][5]. **CGMP** is a peptide derived from kappa-casein during cheese production; it is naturally low in phenylalanine but deficient in several essential amino acids (histidine, leucine, methionine, tryptophan, tyrosine) and therefore must be supplemented accordingly for complete nutritional adequacy[1][4]. CGMP-based substitutes offer an alternative to synthetic free amino acid (L-AA) protein substitutes, with potential advantages including improved palatability and possible metabolic benefits such as slower amino acid absorption and improved nitrogen retention[1][5]. Products are typically further fortified with vitamins, minerals, and sometimes other nutrients.

Brand names

PKU spherePhenylAde GMPGlytactinother GMP-based PKU medical foods

Other names

casein glycopeptidecasein macropeptideglycomacropeptidekappa-casein glycomacrompeptidecaseinoglycomacrompeptide