casein phosphopeptide amorphous calcium phosphate

Casein phosphopeptide amorphous calcium phosphate (CPP-ACP), often marketed under the trademark RECALDENT, is a bioactive milk-derived protein complex used in preventive dentistry. It consists of casein phosphopeptides (CPP) that bind and stabilize calcium and phosphate ions in an amorphous, non-crystalline state (ACP). This complex adheres to tooth surfaces, dental plaque, and surrounding soft tissues, creating a reservoir of bioavailable calcium and phosphate. By maintaining a state of supersaturation relative to tooth enamel, CPP-ACP buffers plaque pH, inhibits demineralization, and promotes the remineralization of early non-cavitated carious lesions (white spot lesions). It is commonly used in topical pastes, varnishes (often in combination with fluoride), and chewing gums to treat dental caries and dentin hypersensitivity.

Brand names

MI PasteTooth MousseRECALDENT

Other names

casein phosphopeptide-amorphous calcium phosphate complex