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CASi-005
- Development stage
- Preclinical
- Lead developer
- Switch Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
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Overview
CASi-005 is a preclinical-stage small interfering RNA (siRNA) therapeutic being developed by Switch Therapeutics. It utilizes the company's proprietary Conditionally Activated siRNA (CASi) platform, which is designed for targeted delivery and activation, specifically optimized for central nervous system (CNS) applications. The CASi platform aims to provide long-lasting gene knockdown with improved safety and potency compared to traditional RNAi approaches. While the specific biological target and primary indication remain undisclosed, the program is part of a pipeline focused on addressing significant unmet needs in neurological disorders.
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