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CASi-500
- Development stage
- Preclinical
- Lead developer
- Switch Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
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Overview
CASi-500 is a preclinical-stage small interfering RNA (siRNA) therapeutic being developed by Switch Therapeutics. It is the lead program utilizing the company's proprietary Conditionally Activated siRNA (CASi) platform, which is engineered to provide potent and durable gene knockdown specifically within the central nervous system (CNS). The CASi platform combines the properties of double-stranded and single-stranded RNA to enhance delivery and activity. While the specific molecular target and primary indication for CASi-500 are currently undisclosed, the program is focused on addressing unmet needs in neurological diseases.
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