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CASi-C1q
- Development stage
- Preclinical
- Lead developer
- Switch Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
CASi-C1q is an investigational RNA interference (RNAi) therapeutic being developed by Switch Therapeutics for the treatment of neuroinflammation and frontotemporal dementia (FTD). Utilizing the company's proprietary CASi (Central-Nervous-System-Accessible-siRNA) platform, the drug is designed to deliver small interfering RNA (siRNA) to the central nervous system to knockdown the expression of C1QA, a subunit of the C1q complement protein. By reducing C1q levels, the therapy aims to modulate complement-driven neuroinflammation, which is a key driver of neurodegeneration in FTD and other CNS disorders. The program is currently in the IND-enabling stage of development.
02
Targets
C1QA (Complement C1q subcomponent subunit A)
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