Drug intelligence / Profile preview

Casigold

Development stage
Unknown
Lead developer
Royal DSM
Modality
Peptides, Small Molecules
Administration
Oral
01

Overview

Casigold is an investigational product studied for its potential to lower blood pressure in individuals with high-normal blood pressure or mild hypertension. In clinical studies, Casigold was administered as capsules containing a total of 15 mg of the tripeptide isoleucine-proline-proline (IPP) per day over a period of four weeks. The primary objective was to demonstrate a blood pressure-lowering effect, while secondary objectives included collecting safety data and exploring mechanisms by measuring renin and angiotensin I and II levels, as well as evaluating genetic determinants related to blood pressure response. Casigold appears to be derived from bioactive peptides, specifically IPP, which are known angiotensin-converting enzyme (ACE) inhibitors that may exert antihypertensive effects by inhibiting the conversion of angiotensin I to angiotensin II—a key step in regulating vascular tone and fluid balance[3]. The study design was randomized, placebo-controlled, double-blind, and cross-over[3].

Other names
casigold
02

Targets

ACE (Angiotensin Converting Enzyme)

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