casiopeina IIgly

**Casiopeina IIgly** is a mixed chelate **copper(II) coordination compound** in the Casiopeínas family, developed as a novel antineoplastic agent. Its mechanism of action includes the generation of **reactive oxygen species (ROS)** via redox cycling with glutathione (GSH), causing **oxidative stress**, rapid depletion of cellular GSH, mitochondrial dysfunction, membrane depolarization, and mitochondrial DNA damage. These activities collectively lead to metabolic disruption and **cell death** in several cancer cell lines, including lung, breast, and cervical cancer cells[1][2][3][5]. It also interacts with DNA and induces apoptosis and autophagy in tumor cells, while showing selectivity for malignant over normal cells[2][5].

Brand names

Casiopeína IIgly

Other names

Cu(4,7-dimethyl-1,10-phenanthroline)(glycinate)]NO3CasIIgly