caspase-3 small interfering RNA

Caspase-3 small interfering RNA (siRNA) is a synthetic RNA molecule designed to silence the caspase-3 gene through RNA interference (RNAi), thereby inhibiting the production of the caspase-3 protein, a key mediator of apoptosis and inflammation[1][2]. By reducing caspase-3 expression, this approach aims to protect tissues from ischemia-reperfusion injury and apoptotic cell death. In preclinical studies, serum-stabilized caspase-3 siRNA delivered both locally (into the renal artery during cold storage) and systemically (intravenously) significantly reduced caspase-3 mRNA and protein levels, decreased apoptosis and inflammation, and improved renal function in a porcine kidney autotransplantation model[1]. The drug’s effect was associated with reduced HMGB1 release and favorable modulation of inflammatory cytokines. No off-target effects or significant toxicity were reported in these animal studies. Development is primarily at the preclinical stage, with no approved therapies for human use as of current knowledge.

Other names

caspase-3 RNAicaspase3 RNAicaspase 3 RNAicaspase-3 shRNAcaspase3 shRNAcaspase 3 shRNAcaspase-3 gene silencing RNAcaspase3 gene silencing RNAcaspase 3 gene silencing RNAcaspase-3 short interfering RNAcaspase3 short interfering RNAcaspase 3 short interfering RNA