Drug intelligence / Profile preview

Castor oil

Development stage
Unknown
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Oral, Topical
01

Overview

Castor oil is a vegetable oil derived from the seeds of the castor bean plant (Ricinus communis). It is primarily used as an over-the-counter stimulant laxative to treat constipation and for bowel evacuation prior to medical procedures. The main active component is ricinoleic acid, which constitutes about 90% of the fatty acids in castor oil. The pharmacological effects are mediated by ricinoleic acid released by intestinal lipases; it acts as a selective agonist at Prostaglandin E receptor 3 (EP3) on smooth muscle cells in the intestine and uterus, promoting increased intestinal motility (laxation) and uterine contractions. Castor oil is also used topically as an emollient for skin and hair care[1][2][3][4][6][7].

Brand names
Fleet Castor OilEmulsoil
Other names
Ricinus communisriccinus oilcastor oil
02

Targets

PTGER3 (Prostaglandin E2 receptor EP3 subtype)

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