Drug intelligence / Profile preview

CAT-179

Development stage
Preclinical
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

CAT-179 is an allogeneic natural killer (NK) cell therapy product engineered to express a chimeric antigen receptor (CAR) targeting HER2, as well as interleukin-15 (IL-15) and transforming growth factor beta (TGFβ). This design aims to enhance NK cell persistence, proliferation, and anti-tumor activity while overcoming immunosuppressive signals in the tumor microenvironment. The primary indication under investigation for CAT-179 is renal cell carcinoma. As of the latest available information, development is at the preclinical stage[2].

02

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)IL15 (Interleukin 15)TGFB (GARP–latent transforming growth factor beta 1 complex)

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