Drug intelligence / Profile preview

Catiolanze

Development stage
Phase 3
Lead developer
Santen Pharmaceutical
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Catiolanze is a prescription ophthalmic emulsion formulation of the prostaglandin F2α analogue latanoprost, developed as a cationic emulsion to enhance ocular surface tolerability while lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension, including children from 4 years of age with elevated intraocular pressure or paediatric glaucoma.[1][5][14] As a hybrid medicine referencing Xalatan, it contains the same active substance but in an oil‑in‑water emulsion rather than solution, and acts as a selective FP receptor agonist that increases uveoscleral outflow (and to a lesser extent trabecular outflow), thereby reducing intraocular pressure and the risk of glaucomatous damage.[1][5][14] The product was developed and is marketed in the EU by Santen, with EU‑wide approval granted in November 2023 based on non‑inferiority to latanoprost solution in phase III trials and improved ocular surface endpoints.[1][4][6][16]

Brand names
Catiolanze
Other names
preservative-free latanoprost cationic emulsion
02

Targets

PTGFR (Prostaglandin F2 alpha receptor)

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