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cationic exchange resin
- Development stage
- Preclinical
- Lead developer
- Vera Salus Ricerca
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Oral
01
Overview
The cationic exchange resin being developed by Vera Salus Ricerca is an orally administered therapeutic candidate currently in the IND-enabling phase for the treatment of hyperkalemia. As a cationic exchange resin, the drug functions within the gastrointestinal tract by binding excess potassium ions in exchange for other cations, such as sodium or calcium. This sequestration prevents the absorption of potassium into the bloodstream and promotes its elimination through the feces, thereby reducing serum potassium levels. This mechanism is particularly relevant for patients with chronic kidney disease or heart failure who are at high risk for life-threatening potassium elevation, often exacerbated by the use of renin-angiotensin-aldosterone system (RAAS) inhibitors.
- Other names
- cationic exchange resins
02
Targets
Calcium and magnesium ions in the gastrointestinal lumen
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