Drug intelligence / Profile preview

Caudal Epidural Injection with DepoMedrol

Development stage
Phase 4
Lead developer
Pain Management Center of Paducah
Modality
Small Molecules
Administration
Epidural
01

Overview

Caudal Epidural Injection with DepoMedrol is a procedural drug intervention developed and evaluated by the Pain Management Center of Paducah for the treatment of chronic low back pain and related spinal conditions. The intervention consists of a co-administered mixture of methylprednisolone acetate (brand name: DepoMedrol), a synthetic glucocorticoid corticosteroid manufactured by Pfizer, and lidocaine, an amide local anesthetic. Administered via caudal epidural injection through the sacral hiatus under fluoroscopic guidance, the combination targets the inflammatory cascade and nerve root irritation in the epidural space. It has been evaluated in randomized, double-blind clinical trials (such as NCT00370799) for indications including lumbar disc herniation, spinal stenosis, discogenic pain, and post-lumbar laminectomy syndrome.

Brand names
Depo-Medrol with LidocaineDepo-Medrone with Lidocaine
Other names
Caudal Epidural Injection with Depo-MedrolCaudal Epidural Injection with methylprednisolonelidocaine + methylprednisolonelidocaine + methylprednisolone acetate
02

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)NaV (Voltage-gated sodium channels)

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