Drug intelligence / Profile preview

cayratia japonica gel

Development stage
Unknown
Lead developer
National Anorectal Center of Nanjing Hospital of Chinese Medicine
Modality
Hydrogel Systems → Drug Delivery Systems, Small Molecules
Administration
Topical
01

Overview

Cayratia japonica gel is a topical Traditional Chinese Medicine (TCM) preparation developed by the Nanjing Hospital of Chinese Medicine (Affiliated to Nanjing University of Chinese Medicine). It is primarily indicated for the treatment of postoperative wounds following anal fistula surgery to promote healing and reduce complications such as pain, edema, and exudation. The gel is formulated from the extract of *Cayratia japonica* (also known as Bushkiller or Wulianmei), which contains bioactive constituents including flavonoids, terpenoids, and phenolic acids. Its mechanism of action involves potent anti-inflammatory effects by inhibiting pro-inflammatory cytokines such as TNF-alpha and IL-1 beta, as well as promoting the expression of growth factors like VEGF to accelerate granulation tissue formation and re-epithelialization. Additionally, it exhibits antimicrobial properties that help prevent local infections at the surgical site.

Other names
Wulianmei gelWulianmei NingjiaoCayratia japonica (Thunb.) Gagnep. gel
02

Targets

MAOB (Monoamine oxidase B)MAOA (Monoamine oxidase A)

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