Drug intelligence / Profile preview

CBD Body Relief

Development stage
Preclinical
Lead developer
Global Widget
Modality
Small Molecules
Administration
Topical
01

Overview

CBD Body Relief is a topical analgesic formulation, typically available as a gel or cream, that combines hemp-derived cannabidiol (CBD) with counter-irritants such as menthol. It is designed to provide localized relief from musculoskeletal pain, including muscle soreness, joint stiffness, and inflammation. The product's efficacy is derived from a multi-target approach: menthol provides an immediate cooling sensation by activating TRPM8 receptors on sensory neurons, while CBD interacts with the peripheral endocannabinoid system, potentially modulating pain signaling and inflammatory cytokine production through its action as a negative allosteric modulator of CB1 and CB2 receptors. As a consumer-grade hemp product, it is widely used for minor aches associated with arthritis, backaches, and physical exertion.

Brand names
CBD Body ReliefHemp Bombs CBD Body ReliefNature's Script CBD Body Relief
Other names
CBD Pain Relief GelCBD Muscle Rub
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))TRPV1 (Transient receptor potential cation channel subfamily V member 1)GPR55 (G protein-coupled receptor 55)CNR1 (Cannabinoid receptor 1)MOR (Mu opioid receptor)TRPV2 (Transient receptor potential cation channel subfamily V member 2)PPARG (Peroxisome proliferator-activated receptor gamma)

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