Drug intelligence / Profile preview

CBP-1029

Development stage
Preclinical
Lead developer
Coherent Biopharma
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

CBP-1029 is a bispecific antibody-drug conjugate (ADC) being developed by Coherent Biopharma for the treatment of solid cancers. It utilizes the company's proprietary Bi-XDC (bi-targeting ligand-drug conjugate) technology platform to deliver a topoisomerase inhibitor payload directly to tumor cells. The Bi-XDC platform is designed to enhance tumor specificity and therapeutic index by targeting two distinct antigens simultaneously. While the specific molecular targets for CBP-1029 have not been publicly disclosed, the drug is part of a pipeline of next-generation conjugates aimed at overcoming resistance and reducing systemic toxicity in oncology. It is currently in the early stages of development.

02

Targets

TOP (DNA topoisomerases)

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