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Drug intelligence / Profile preview
CBT-009
- Development stage
- Phase 2
- Lead developer
- Cloudbreak Pharma
- Modality
- Classical Binding Small Molecules → Small Molecules, Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Ophthalmic
01
Overview
CBT-009 is a novel ophthalmic formulation of atropine developed by Cloudbreak Therapeutics for the treatment of juvenile myopia. Unlike traditional aqueous formulations, CBT-009 is a non-aqueous, preservative-free eye drop designed to enhance the stability and bioavailability of atropine while reducing degradation and microbial growth. This formulation allows for multi-dose packaging without preservatives and requires lower dosages due to improved drug stability and ocular surface residence time. Atropine acts as an anticholinergic agent—specifically a muscarinic receptor antagonist—blocking neurotransmitter action in both central and peripheral nervous systems to slow myopia progression in children[1][2][4][5].
- Other names
- atropine ophthalmicnon-aqueous atropine eye drop0.025% atropine sulphateAtropine sulfate - Cloudbreak Therapeutics
02
Targets
mAChR (Muscarinic acetylcholine receptors)AChR (Acetylcholine receptor)
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