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CBT-104C is an engineered bacterial therapeutic being developed by CommBio Therapeutics for the treatment of rheumatoid arthritis (RA). As a live biotherapeutic product (LBP), it utilizes synthetic biology to genetically modify bacterial strains to deliver therapeutic effects directly within the host. These modifications are typically designed to modulate the immune system, produce anti-inflammatory metabolites, or deliver therapeutic payloads to the gut-joint axis. The drug is part of CommBio's CBT-104 series, which targets various autoimmune and inflammatory conditions. It is currently in the clinical research stage, which corresponds to Phase 1 development.
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