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CBT-10X

Development stage: Preclinical
Lead developer: CommBio Therapeutics
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

CBT-10X is an engineered bacterial therapeutic being developed by CommBio Therapeutics for the treatment of colorectal cancer and conditions involving the brain-gut axis. As a live biotherapeutic product (LBP), it utilizes synthetic biology to modify bacteria to perform therapeutic functions within the gastrointestinal tract. The program is designed to leverage the microbiome's role in oncology and systemic signaling, potentially through the localized delivery of therapeutic payloads or the modulation of metabolic pathways. It is currently in the preclinical stage of development.

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