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CC-90001
- Development stage
- Phase 1
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
CC-90001 is an orally bioavailable, selective, small-molecule inhibitor of c-Jun N-terminal kinase 1 (JNK1; also known as mitogen-activated protein kinase 8 or MAPK8), with a strong bias for JNK1 over JNK2. It is a second-generation JNK inhibitor developed for its potential antineoplastic, anti-inflammatory, and antifibrotic activities. By inhibiting the activity of JNK1, CC‑90001 disrupts MAPK-mediated signaling pathways involved in cell proliferation, migration, invasion, and fibrosis. This mechanism may induce cell cycle arrest and apoptosis in cancer cells and reduce fibrotic processes in diseases such as idiopathic pulmonary fibrosis (IPF). The drug has been investigated primarily for IPF in phase 2 clinical trials[1][4][5][6][7].
- Other names
- 1403859-14-2JD5ZWE631KJD-5ZWE631KJD 5ZWE631KCHEMBL4847106CHEMBL-4847106CHEMBL 4847106
02
Targets
OATP1B1 (Organic anion transporting polypeptide 1B1)SLC47A1 (Multidrug and toxin extrusion transporter 1)ABCG2 (Breast cancer resistance protein)UGT1A4 (UDP-glucuronosyltransferase 1A4)JNK (Mitogen-activated protein kinase kinase kinase family)UGT1A9 (UDP-glucuronosyltransferase 1A9)ABCB1 (P-glycoprotein)SLC22A8 (Organic anion transporter 3)SLCO1B3 (Organic anion transporting polypeptide 1B3)JUN (Transcription factor Jun)OCT2 (Organic cation transporter 2)CYP2B6 (Cytochrome P450 2B6)MATE2-K (Multidrug and toxin extrusion protein 2)UGT1A1 (UDP-glucuronosyltransferase 1A1)
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