CC-90011 + itraconazole

**CC-90011 + itraconazole** is a combination regimen of two pharmaceutical drugs: CC-90011 (also called pulrodemstat), a potent, selective, and reversible oral inhibitor of lysine-specific demethylase 1 (LSD1), and **itraconazole**, an antifungal agent. CC-90011 blocks LSD1, a key regulator of gene expression implicated in cancer progression, particularly neuroendocrine tumors and acute myeloid leukemia[2][5][7][9]. Itraconazole is conventionally used for fungal infections but has additionally demonstrated off-target activity in oncology through inhibition of angiogenesis and the Hedgehog signaling pathway. This combination may be explored for potential synergistic anti-tumor activity in clinical trials.

Other names

CC90011 + itraconazole