Drug intelligence / Profile preview

CC-98633

Development stage
Phase 1
Lead developer
Bristol Myers Squibb
Modality
CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

CC-98633 is an autologous chimeric antigen receptor (CAR) T cell therapy that targets B-cell maturation antigen (BCMA), a protein highly expressed on malignant plasma cells in multiple myeloma. Upon administration, the engineered T cells specifically recognize and kill BCMA-expressing tumor cells. The therapy uses the NEX-T platform for CAR design and is being developed primarily for relapsed or refractory multiple myeloma. Clinical trials have evaluated its safety, tolerability, pharmacokinetics/pharmacodynamics, and efficacy in this patient population[1][2][3][4][5][7].

Other names
autologous BCMA-targeted CAR-T cells CC-98633
02

Targets

BCMA (B-cell maturation antigen)

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