Drug intelligence / Profile preview

CC49-mal-MMAE

Development stage: Discontinued
Lead developer: City of Hope
Modality: Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intraperitoneal, Intravenous, Intramuscular, Subcutaneous, Intradermal, Topical

Overview

**CC49-mal-MMAE** is a preclinical, TAG-72-targeted antibody-drug conjugate developed at City of Hope for ovarian cancer research. It consists of the murine anti-tumor-associated glycoprotein 72 antibody CC49 conjugated through reduced hinge-region disulfides to the antimicrotubule payload monomethyl auristatin E using maleimido linker chemistry. The construct had a high drug-to-antibody ratio of approximately 9.5 but showed rapid blood clearance and low OVCAR3 xenograft tumor uptake relative to the corresponding bromoacetamido-linked CC49-MMAE conjugate, and it was ineffective in the reported ovarian cancer xenograft efficacy study.

Other names: CC49-mal-MMAECC-49-mal-MMAECC 49-mal-MMAE

Targets

TAG-72TUBB (Tubulin (alpha and beta subunits))

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