CCN5 recombinant protein

CCN5 recombinant protein (also known as rh-CCN5 or WISP2) is a recombinant human protein derived from the CCN family of matricellular proteins, encoded by the WISP2/CCN5 gene. It is currently a research-stage compound with no approved brand name or single developing pharmaceutical company, primarily available as a research reagent from multiple suppliers. Preclinical studies have investigated its potential in promoting pancreatic beta-cell proliferation and survival for diabetes therapy, as well as inhibiting anti-VEGF drug-induced epithelial-mesenchymal transition (EMT) in retinal pigment epithelium cells. Its biological targets include cell-cycle regulators such as CDK4 and cyclin D1, and it has been shown to modulate CCN2 expression.

Other names

CCN5rpCCN-5rpCCN 5rpcellular communication network factor 5Connective tissue growth factor-like proteinConnective tissue growth factor-related protein 58CT58CT-58CT 58CTGF-LCTGFLhrCCN5hrCCN-5hrCCN 5recombinant human CCN5rh-CCN5rh-CCN-5rh-CCN 5rhCCN5rhCCN-5rhCCN 5WISP-2WISP2WISP 2WNT1-inducible-signaling pathway protein 2WNT-1-inducible-signaling pathway protein 2WNT 1-inducible-signaling pathway protein 2