Drug intelligence / Profile preview

CD-70 CAR-NK

Development stage
Preclinical
Lead developer
University of Texas MD Anderson Cancer Center
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous, Intraperitoneal
01

Overview

CD-70 CAR-NK is an allogeneic Chimeric Antigen Receptor Natural Killer (CAR-NK) cell therapeutic. It is designed to target the CD70 antigen, which is frequently overexpressed in various hematologic and solid tumors. This cell therapy leverages the precision targeting of a CAR, engineered to recognize CD70, combined with the innate cytotoxic mechanisms of Natural Killer (NK) cells. This approach aims to provide an "off-the-shelf" immunotherapy with potential advantages over CAR-T cells, such as a reduced risk of graft-versus-host disease (GvHD). The therapeutic is in preclinical and early-stage clinical development for multiple cancer indications. TC BioPharm is in the process of acquiring a proprietary manufacturing process for this therapeutic.

02

Targets

CD70 (Cluster of Differentiation 70)

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