Drug intelligence / Profile preview

CD16-MUC1 bispecific antibody

Development stage
Preclinical
Lead developer
Benhealth Biopharmaceutical
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

CD16-MUC1 bispecific antibody is a preclinical-stage therapeutic candidate being developed by Benhealth Biopharmaceutical. It is designed as a bispecific immune cell engager that simultaneously binds to CD16 (FcγRIII) on effector cells, such as natural killer (NK) cells and macrophages, and Mucin 1 (MUC1), a glycoprotein overexpressed on the surface of various tumor cells. By facilitating the proximity between immune effector cells and MUC1-positive cancer cells, the antibody triggers antibody-dependent cellular cytotoxicity (ADCC) and other immune-mediated killing mechanisms. This approach is intended for the treatment of MUC1-expressing solid tumors, including breast, lung, and pancreatic cancers.

Other names
CD16 x MUC1 bispecific antibodyCD-16 x MUC1 bispecific antibodyCD 16 x MUC1 bispecific antibodyMUC1 x CD16 bispecific antibodyMUC-1 x CD16 bispecific antibodyMUC 1 x CD16 bispecific antibodyanti-CD16 x anti-MUC1 bispecific antibodyanti-CD-16 x anti-MUC1 bispecific antibodyanti-CD 16 x anti-MUC1 bispecific antibody
02

Targets

FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)MUC1 (Mucin-1 Antigen)FCGR3B (Fc gamma receptor III)

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