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CD19 and CD22 targeted CAR-T cells (Gracell Biotechnologies)
- Development stage
- Unknown
- Lead developer
- Gracell Biotechnologies
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
CD19 and CD22 targeted CAR-T cells refers to a dual-antigen chimeric antigen receptor (CAR) T-cell therapy designed to treat B-cell malignancies. By targeting both CD19 and CD22, these cells aim to reduce the risk of relapse caused by antigen escape, which occurs when cancer cells lose the expression of a single target (like CD19) under selective pressure. The specific program described in the context utilizes the FasT CAR-T manufacturing platform, developed by Gracell Biotechnologies (now part of AstraZeneca), which significantly reduces the production time to approximately 24 hours while preserving the T-cell stemness and proliferative capacity. This approach is being investigated for patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (B-NHL) and acute lymphoblastic leukemia (ALL).
- Other names
- CD19/CD22 dual-targeted CAR-T cellsCD19/CD22 FasT CAR-T
02
Targets
CD19 (B lymphocyte antigen CD19)CD22 (Cluster of Differentiation 22)
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